A new framework for human biology
Every -omics company measures one layer. Nobody measures what happens when they interact in a person shaped by their own history. That interaction is the Originome.
The Concept
The genome is your blueprint. The epigenome is what experience switched on and off. The exposome is every environmental input. The metabolome, microbiome, and proteome are your body's current operating state. Each is measured in isolation. Nobody measures the emergent state that arises from their interaction across a person's history.
Genome
Your inherited genetic blueprint. Static, but expressed differently depending on everything else.
Epigenome
What experience has switched on and off. Modified by adversity, environment, and time. Heritable across generations.
Exposome
Every environmental input across your lifespan: air, water, chemicals, nutrition, safety, stability.
Metabolome
Your body's current chemical state. The metabolic signature of how all systems are functioning right now.
Microbiome
The microbial ecology that modulates immunity, brain function, and metabolism.
Proteome
The proteins your cells are actually producing. The functional output of gene expression in context.
The Originome is the path-dependent biological state that emerges from the interaction of all -omes across a person's development, environment, and history. It is the biological sum of where you came from, what you lived through, and what your body is doing about it right now. Everyone has one.
First Application
A woman's fertility timeline is shaped by her grandmother's environment, her inherited epigenetic programming, her own stress biology, and the conditions she lives inside. Every -ome converges on one measurable outcome: how her ovarian reserve changes over time.
No existing product integrates these layers. Hormone tests give you a snapshot. Cycle apps give you a chart. Genetic tests give you static risk. Nobody connects them to your family history, your adversity, or your environment.
The Reproductive Originome Profile does.
See What You GetFamily reproductive history
Maternal line mapping across 2-3 generations
Cycle trajectory analysis
Longitudinal patterns, not single-month snapshots
Ovarian reserve context
AMH and hormones interpreted through the full picture
Stress and adversity biology
Life circumstances as biological input, not footnote
Environmental context
Geocoded exposure data from where you live
Autonomic profile
Wearable data revealing your nervous system's state
The Opportunity
$30B+
Global fertility services market
$70B
Epigenetic diagnostics market by 2034
1 in 6
People worldwide affected by infertility
The epigenetic diagnostics market is dominated by oncology. Fertility is barely represented despite being one of the most biologically obvious applications of how experience becomes biology.
The Evidence
The Originome concept rests on converging evidence from transgenerational epigenetics, developmental biology, allostatic load research, and multi-omic integration studies.
Nature Communications, 2025
Prenatal environmental exposure caused transgenerational inheritance of diminished ovarian reserve through F1-F3 generations via persistent DNA hypomethylation. The methylation signatures are detectable in blood.
Transgenerational Epigenetics
Ancestral toxicant exposure produces hundreds of differentially methylated regions in granulosa cells of F3 generation animals. What the grandmother experienced is written in the granddaughter's ovaries.
Stress & Fertility
Chronic psychosocial stress is an independent predictor of diminished ovarian reserve, controlling for age and family history. Adversity is a biological input to reproductive aging.
Epigenetic Clocks
DunedinPACE measures the pace of biological aging from blood methylation and responds to adversity exposure. Epigenetic age acceleration predicts reproductive outcomes.
The Vision
Once proven in reproductive health, the same framework applies wherever the body carries history. Same technology. Same reference system. Different questions.
Why do two people with the same diagnosis have different biology? Because their Originomes are different.
Why does this patient cycle through specialists with no answers? Because nobody reads the cross-system Originome.
What is the biological cost of structural adversity on communities? The collective Originome makes it visible.
Why does one patient respond to treatment and another doesn't? Different Originomes, same diagnosis.
How is a child's environment shaping their biology right now? The developmental Originome measures it.
What did ancestors carry forward? What is each person writing into their own Originome? The deepest question.
Originome grows out of a decade of research into the question at the center of stress neuroscience: how does life become body? How do the conditions a person lives inside get written into their biology across systems, across time, and across generations?
Five peer-reviewed publications in stress neurocircuitry, gut-brain signaling, and perinatal pharmacology. NIH-funded research. And a personal history that made the question more than academic.
Originome exists to build the measurement and interpretation layer that connects life conditions to biological state. The first application is reproductive health, because the intergenerational science is the strongest, the stakes are the most time-sensitive, and the gap in the market is the widest.
The Reproductive Originome Profile is coming soon. Join the waitlist to be among the first to access it.
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